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Saturday, October 21, 2017

MS Focus Lending Library

There is a great deal of helpful and inspirational material about MS available today. At MS Focus, we understand that not everyone has access to the wide range of resources out there. That is why we maintain a Lending Library, where books, DVDs, and CDs are all available for loan -- at no charge to you -- through the mail. Items can be sent across the United States, so, no matter where you live, you can benefit from these materials.
You may request as many items for loan as you wish. Requested materials will be sent one item at a time.  When a returned item is received by MS Focus, the next requested item will be mailed to you, if available.  Some items may have a waiting list. To verify availability of an item, call 888-MSFocus (673-6287) or email library@msfocus.org.

MS Focus Lending Library


Books, DVDs, and CDs are available for loan, by mail across the United States.
Learn more

Study uncovers potential risks of common MS treatment


Study finds an increased risk of events such as stroke, migraine, and depression, and abnormalities in the blood with taking beta interferon for MS.
Learn more
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MS Views and News provides beneficial Multiple Sclerosis education, information, resources and services. 
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Looking into cognitive impairment in Primary-Progressive Multiple Sclerosis.

Petracca M, et al. Eur J Neurol. 2017.

Abstract

BACKGROUND: Cognitive impairment in primary-progressive multiple sclerosis (PP-MS) is correlated with global brain atrophy. Unfortunately, brain volumes computation requires processing resources not widely available in clinical practice. Therefore we decided to test the predictive role of retinal atrophy metrics on cognitive decline, applying them as proxy of grey matter (GM) atrophy in PP-MS.
METHODS: Twenty-five PP-MS patients completed the Brief International Cognitive Assessment for MS (BICAMS) and underwent spectral-domain OCT and 3.0 Tesla MRI. Through a stepwise logistic regression we tested whether OCT metrics (retinal nerve fiber layer-RNFL, ganglion cell+inner plexiform layer-GCIPL, total macular volume-TMV) predicted cognitive impairment and explored the role of GM atrophy in mediating these correlations.
RESULTS: Among OCT metrics, only GCIPL was associated with cognitive impairment (rp =.448, p=.036) and predictive of objective cognitive impairment (Wald [1]=4.40, p=.036). Controlling for demographics, normalized brain volume (NBV) and thalamic volume were correlated with GCIPL (respectively rp =.427, p=.047 and rp =.674, p=.001) and cognitive scores (respectively rp =.593, p=.004 and rp =.501, p=.017), with thalamic volume nearly mediating the association between GCIPL and cognition (Sobel z=1.86, p=.063).
CONCLUSIONS: GCIPL thickness is a suitable measure of neurodegeneration. In comparison with brain atrophy, GCIPL offers higher histopathological specificity, being a pure correlate of neuronal loss and may be a noninvasive, easy-to-perform way to quantitatively evaluate and monitor neuronal loss related to cognitive impairment in PP-MS. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.

PMID

 29053884 [PubMed - as supplied by publisher]


MS Views and News provides beneficial Multiple Sclerosis education, information, resources and services. 
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Homecare Assistance Grants

MS Focus understands the daily needs and challenges that must be met by both those with MS and their caregivers. In order to meet these needs in the most timely and efficient way possible, our Homecare Assistance Grant connects you to the best available local services. Should resources within your community not be available, direct support may be provided on a temporary basis.

Available Services include

  • Home Care - Personal hygiene services, light housekeeping, grocery shopping, meal preparation, and transportation to and from appointments are all services that can be provided for a limited time.
  • Therapy Visits - Based upon individual need, an appointment with an occupational, physical, or speech therapist can be arranged. Through education and training, these therapists can help to foster independence, self-esteem, and better quality of life for the person living with MS.
  • Respite Care -  Respite allows primary caregivers the opportunity to tend to themselves, or other family business, with the assurance that their loved one is being cared for by a properly trained individual. This service is provided on a short-term basis for a scheduled period of time. 
  • Coming Home - Returning home from a stay at the hospital can be a difficult time of transition. We offer a four-hour visit from an aide who will meet the patient at the hospital, provide transportation home, and then get the patient settled comfortably at home.
Print Application Online Application 



MS Views and News provides beneficial Multiple Sclerosis education, information, resources and services. 
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Clinical Studies for those affected by MS in South Florida

CURRENTLY ENROLLING CLINICAL TRIALS - SUNRISE NEUROLOGY
Located in Sunrise, Fl. (Broward County)


For detail of Sunrise Neurology enrolling clinical trials,




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Aging with MS


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Overview

We all grow older- including people with MS. MS is often described as a disease of young and middle aged adults. Yet a significant number of all people living with MS are 65 or older.
Until recently, little attention was paid to the issues or challenges of aging with MS, and very few resources or services specifically designed for older adults with MS were readily available. However, there is a growing interest in aging with MS and recognition that more attention must be paid to this important topic.

Additional resources

Aging Life Care Association- Serves seniors, adults with disabilities (of any age), and families who need assistance with caregiving issues.
Eldercare Locator- information and assistance resources.
National Council on Aging- assists seniors in improving their health, living independently and remaining active.
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MS Views and News provides beneficial Multiple Sclerosis education, information, resources and services. 
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National MS Society Response to Executive Order on Health Care


October 12, 2017

“The Executive Order released this morning is absolutely the wrong approach for people living with MS,” said Bari Talente, Executive Vice President of Advocacy for the National MS Society. “This order erodes protections in health insurance that are critically important to people with chronic and high-cost health care needs. 

This Executive Order both undermines bipartisan efforts to find solutions for our nation’s healthcare system and is another step to damage the Affordable Care Act.

Rolling back critical protections will create more health insurance options that shortsightedly may serve the needs of younger or currently healthy people, but at the expense of others like older or sicker people whose costs will be driven up, and those currently healthy who find themselves facing a healthcare crisis. 

The destabilizing effects of this Executive Order will be devastating for the individual insurance market and potentially the entire health insurance system.”

Learn more about the Society’s work on access to affordable, quality health insurance coverage



MS Views and News provides beneficial Multiple Sclerosis education, information, resources and services. 
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Print Global Experts Publish Recommendations for Overcoming Challenges to Improve Clinical Trials in Progressive MS


October 18, 2017

  • special issue of Multiple Sclerosis Journal, sponsored by the International Progressive MS Alliance, has been published, containing ten papers that review the challenges and the potential solutions to improving clinical trials and their outcomes so that new treatments become available for people living with progressive MS.
  • Progressive MS is a form of MS that gets worse over time. Each day, progressive MS takes things away from people: vision, mobility, cognition, ability to work, and their very independence. MS is found in every country where studies have been conducted, and more than 2.3 million people worldwide currently live with the disease; over 1 million people live with a progressive form of MS.
  • The special issue includes articles on many aspects of trial design, lessons learned, and research gaps, and includes a paper by a person living with MS, urging researchers to involve people with MS in every stage of planning and conducting clinical trials so that they are relevant to the treatment needs of people with progressive MS.
  • As a result of the sponsorship by the Alliance, the full content of the special issue, “Advancing Trial Design In Progressive Multiple Sclerosis,” may be read by anyone by following links below.
  • The papers stemmed from participants involved in a workshop convened in Rome in March 2017 under the auspices of the European Committee for Treatment and Research in MS (ECTRIMS) and the International Progressive MS Alliance.
  • Together, the papers provide a comprehensive roadmap for planning and conducting clinical trials and further research needed to develop new therapies that can slow or stop progressive MS. 



MS Views and News provides beneficial Multiple Sclerosis education, information, resources and services. 
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Long-term disability progression in primary progressive multiple sclerosis: a 15-year study.

Rocca MA, et al. Brain. 2017.

Abstract

Prognostic markers of primary progressive multiple sclerosis evolution are needed. We investigated the added value of magnetic resonance imaging measures of brain and cervical cord damage in predicting long-term clinical worsening of primary progressive multiple sclerosis compared to simple clinical assessment. In 54 patients, conventional and diffusion tensor brain scans and cervical cord T1-weighted scans were acquired at baseline and after 15 months.

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MS Views and News provides beneficial Multiple Sclerosis education, information, resources and services. 
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Magnetization transfer ratio measures in normal-appearing white matter show periventricular gradient abnormalities in multiple sclerosis.

Magnetization transfer ratio measures in normal-appearing white matter show periventricular gradient abnormalities in multiple sclerosis.

Liu Z, et al. Brain. 2015.

Abstract

In multiple sclerosis, there is increasing evidence that demyelination, and neuronal damage occurs preferentially in cortical grey matter next to the outer surface of the brain. It has been suggested that this may be due to the effects of pathology outside the brain parenchyma, in particular meningeal inflammation or through cerebrospinal fluid mediated factors. White matter lesions are often located adjacent to the ventricles of the brain, suggesting the possibility of a similar outside-in pathogenesis, but an investigation of the relationship of periventricular normal-appearing white matter abnormalities with distance from the ventricles has not previously been undertaken. The present study investigates this relationship in vivo using quantitative magnetic resonance imaging and compares the abnormalities between secondary progressive and relapsing remitting multiple sclerosis. Forty-three patients with relapsing remitting and 28 with secondary progressive multiple sclerosis, and 38 healthy control subjects were included in this study. T1-weighted volumetric, magnetization transfer and proton density/T2-weighted scans were acquired for all subjects. From the magnetization transfer data, magnetization transfer ratio maps were prepared. White matter tissue masks were derived from SPM8 segmentations of the T1-weighted images. Normal-appearing white matter masks were generated by subtracting white matter lesions identified on the proton density/T2 scan, and a two-voxel perilesional ring, from the SPM8 derived white matter masks. White matter was divided in concentric bands, each ∼1-mm thick, radiating from the ventricles toward the cortex. The first periventricular band was excluded from analysis to mitigate partial volume effects, and normal-appearing white matter and lesion magnetization transfer ratio values were then computed for the 10 bands nearest to the ventricles. Compared with controls, magnetization transfer ratio in the normal-appearing white matter bands was significantly lower in patients with multiple sclerosis. In controls, magnetization transfer ratio was highest in the band adjacent to the ventricles and declined with increasing distance from the ventricles. In the multiple sclerosis groups, relative to controls, reductions in magnetization transfer ratio were greater in the secondary progressive multiple sclerosis compared with relapsing remitting multiple sclerosis group, and these reductions were greatest next to the ventricles and became smaller with distance from them. White matter lesion magnetization transfer ratio reductions were also more apparent adjacent to the ventricle and decreased with distance from the ventricles in both the relapsing remitting and secondary progressive multiple sclerosis groups. These findings suggest that in people with multiple sclerosis, and more so in secondary progressive than relapsing remitting multiple sclerosis, tissue structural abnormalities in normal-appearing white matter and white matter lesions are greatest near the ventricles. This would be consistent with a cerebrospinal fluid or ependymal mediated pathogenesis.
© The Author (2015). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

PMID

 25823475 [PubMed - indexed for MEDLINE]

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MS Views and News provides beneficial Multiple Sclerosis education, information, resources and services. 
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Neuroinflammation and its relationship to changes in brain volume and white matter lesions in multiple sclerosis.

Datta G, et al. Brain. 2017.

Abstract

Brain magnetic resonance imaging is an important tool in the diagnosis and monitoring of multiple sclerosis patients. However, magnetic resonance imaging alone provides limited information for predicting an individual patient's disability progression. In part, this is because magnetic resonance imaging lacks sensitivity and specificity for detecting chronic diffuse and multi-focal inflammation mediated by activated microglia/macrophages. The aim of this study was to test for an association between 18 kDa translocator protein brain positron emission tomography signal, which arises largely from microglial activation, and measures of subsequent disease progression in multiple sclerosis patients. Twenty-one patients with multiple sclerosis (seven with secondary progressive disease and 14 with a relapsing remitting disease course) underwent T1- and T2-weighted and magnetization transfer magnetic resonance imaging at baseline and after 1 year.

Positron emission tomography scanning with the translocator protein radioligand 11C-PBR28 was performed at baseline. Brain tissue and lesion volumes were segmented from the T1- and T2-weighted magnetic resonance imaging and relative 11C-PBR28 uptake in the normal-appearing white matter was estimated as a distribution volume ratio with respect to a caudate pseudo-reference region.

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MS Views and News provides beneficial Multiple Sclerosis education, information, resources and services. 
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